‘Genome gating’; polarized intranuclear trafficking of influenza virus RNPs
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چکیده
منابع مشابه
'Genome gating'; polarized intranuclear trafficking of influenza virus RNPs.
Many viruses exploit cellular polarity to constrain the assembly and release of progeny virions to a desired surface. Influenza virus particles are released only from the apical surface of epithelial cells and this polarization is partly owing to specific targeting of the viral membrane proteins to the apical plasma membrane. The RNA genome of the virus is transcribed and replicated in the nucl...
متن کاملIntranuclear trafficking
Nucleic acids and regulatory proteins involved in gene expression and DNA replication are localized in specialized subnuclear domains that can be visualized by microscopy. However, the rules that govern the compartmentalization of the nucleus into these discrete domains have been elusive. From an historical perspective, the concept of nuclear subdivisions as functional compartments initially fo...
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Chicken fibroblasts and MDCK cells were infected with influenza virus labelled with either 3H-uridine or 14C-amino acids, and the location in infected cells and properties of input virus-labelled structures were studied. Input virus RNA and protein were found in the cytoplasm of nuclei 1 h p.i. A part of the intranuclear parental structures was associated with chromatin while the other part cou...
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Introduction: The emergence and spread of the pandemic H1N1 influenza virus in 2009 indicates a limitation in the strategy to control the infection, despite a long-established vaccination programme and approved antivirals. Production the proper vaccine against influenza is difficult due to the genetic recombination of virus in the event of pandemic and co-circulation of drug-resistance variants...
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Although the viral factors of host adaptation from domestic poultry to humans have been studied several times since the first cases of direct transmission of highly pathogenic avian influenza viruses from domestic poultry to humans were confirmed in 1997, the host-specific adaptation mechanisms from waterfowl to domestic poultry remain unknown. To study the mechanisms involved, a waterfowl-...
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ژورنال
عنوان ژورنال: Biology Letters
سال: 2005
ISSN: 1744-9561,1744-957X
DOI: 10.1098/rsbl.2004.0253